DNA Double Helix🧬 Biology course
Scored investigationUnit 2 · Cell structure and function Model reasoning

Use the helix model to explain base pairing and strand direction

Three steps, the way the exam actually works: work through the lab, write down your own observations, then answer a 6-point free response. What you recorded goes to the grader with your writing, so a conclusion that does not follow from your own evidence will cost you the point — exactly as it would with a real reader.

1

Run the investigation

  1. 1Rotate the DNA model and identify several A–T and G–C base pairs.
  2. 2Record which bases pair together and which structural parts form the outside of the helix.
  3. 3Trace the two strands visually and note their opposite directions.
  4. 4Use the model to predict how complementarity supports replication.

Booting the lab…

2

Record what you found

This is your reading of the source, not ours. The grader sees them, so your conclusions have to follow from what you actually recorded.

Data table for Use the helix model to explain base pairing and strand direction
Base paired with adenine
Base paired with guanine
What forms the outside backbone
Relationship between strand directions
0/4 entries recorded
3

Answer the free response

Prompt
6 pts

The DNA model makes structure visible. (a) Explain how complementary base pairing supports semiconservative replication. (b) State what “antiparallel” means in DNA and explain why the strands must run in opposite directions for replication enzymes to work correctly. (c) Explain why a change from G–C to A–T can matter even though the helix diameter stays nearly constant. (d) A student says the sugar–phosphate backbone is the information-bearing part of DNA because it is on the outside where enzymes can reach it. Evaluate that claim.

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